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Building a cube has its own set of difficulties and guidelines to consider, so heres an article on the Magic website that talks all about cubes and how to build them for the best playing experience

And of course, Exsanguinate pairs well with lifegain payoffs like Vito, Thorn of the Dusk Rose

In extreme cases where life isn't an issue, you can even cycle through the entire deck to know your choices and then play knowing what is coming, while in situations where life is precious you can usually get by with minimal loss

A card that has been kind of bothering me the more I look at it, is Blasting Station